By / Mar 15

Modern life has a disturbing habit of resembling Arnold Schwarzenegger movies. Take, for example, the 2000 sci-fi thriller ‘The 6th Day’ which featured a pet cloning company called RePet that allowed customers to graft their animal companion’s DNA onto a pre-grown biological blank and within a matter of hours have an exact replica of Spot or Fluffy. RePet promised pet owners: “Should accident, illness or age end your pet’s natural life, our proven genetic technology can have him or her back the same day, in perfect health, with zero defects, GUARANTEED.”

While same-day service is not yet available, pet cloning has been a real—and really expensive—option for more than a decade.

Scientists have been creating genetically identical animals in the laboratory since 1979. But it wasn’t until 1996 that Scottish researchers cloned the first mammal, a sheep named Dolly, by using a mature cell from an adult animal. Six years later, researchers at Texas A&M’s College of Veterinary Medicine & Biomedical Sciences produced the first cloned cat, CC, short for “Carbon Copy.”

By 2004, a California company began taking the first orders for clones of pet cats. Five customers paid $50,000 a piece to have Genetic Savings & Clone perform the cloning procedure. Today, the procedure still costs about $50,000 for dogs but only $25,000 for cats. In a recent interview with Variety, singer Barbara Streisand said she had two dogs cloned from “cells taken from the mouth and stomach of her beloved 14-year-old dog Samantha, who died in 2017.”

Wealthy pet lovers may be disappointed with the results, though, since what they get for their money is not the pet they lost but a genetic replica. As the CEO of the first pet cloning service said,

There are people out there who use the statement that cloning is reproduction not resurrection. But the interesting part from the genetic perspective is that this is resurrection. It is not in terms of a level of consciousness, but in terms of genetics you are getting the same animal back. Personality-wise there are differences.

The result of the “genetic resurrection” is that cloned animals do not necessarily even look like the original pet, much less have the same personality or behavioral characteristics. As David Magnus, co-director of the Center for Biomedical Ethics at Stanford University, noted in 2004, “The people who want this are spending huge sums of money to get their pet immortalized or to guarantee they’re getting a pet exactly like the one they had before—and it’s simply not possible.”

Exploiting the bond between pet lovers and their animals is troubling, especially since genetics has little impact on the characteristics that make animal companionship worthwhile—lovability, personality, shared memories. Arguments against taking advantage of wealthy eccentrics are unlikely to convince people that cloning should not be allowed. The relative rarity of the process also makes it an issue of seemingly minor concern.

But the best time to address the ethics of pet cloning is now, before the process becomes cheaper and more popular. As with many technological advances (think, for example of the cell phone), products and services once limited to the rich eventually become more affordable and more ubiquitous. If pet cloning is unethical, we should develop arguments now to reduce future potential demand.

A primary and biblically justifiable reason for opposing pet cloning is that the cloning process increases the amount of unnecessary animal suffering in the world.

In the process of reproductive cloning, a mature somatic cell, such as a skin cell, is taken from an animal to be copied and its DNA transferred into an egg cell, or oocyte, that has had its own DNA-containing nucleus removed. An electrical current is often used to

fuse the entire somatic cell with the empty egg. After the fusion, the early-stage embryo is implanted into the womb of a surrogate, adult female animal.

Veterinarian Katy Nelson says the cloning process involves a “really expensive, highly scientific puppy mill.”  “These animals are being kept against their will,” adds Nelson “They’re being kept hormonally supplemented, so that they can create these embryos at will.” And as John Hopkins bioethicist Hilary Bok explains,

Cloning causes animals to suffer. Egg donors must have their ovaries artificially stimulated with hormone treatments and their eggs surgically harvested. Given the unusually high rates of late-term miscarriages and high birth weights among clones, the surrogate mothers are at greater risk of dying or suffering serious complications than animals who become pregnant naturally. The clones, themselves, however, suffer the most serious problems: They are much more likely than other animals to be miscarried, have birth defects, develop serious illnesses, and die prematurely.

No pet owner should be willing to allow hundreds of other animals to suffer needlessly just so they can obtain a “genetic replica” of an animal they love. As the book of Proverbs says, “The righteous care for the needs of their animals, but the kindest acts of the wicked are cruel” (Pr. 12:10).

The loss of a family pet can be traumatic and painful. Animals can provide love and companionship, and their effects on their owners should never be mocked or dismissed as a silly, contrived attachment. But nothing fallen humans can do—not even “genetic resurrection”—can bring back that which is lost to the finitude of death. Cloning is not the answer to such loss and grief; it only leads to more unnecessary suffering and death. While beloved pets can’t be replaced, the love they provide can be. It doesn’t require a team of scientists, tens of thousands of dollars, or a morally specious process. All it takes is a trip to the local animal shelter.

Note: In a future article, I’ll examine the moral implications of cloning animals for other reasons.

By / Apr 28

What is cloning?

Cloning is a form of reproduction in which offspring result not from the chance union of egg and sperm (sexual reproduction) but from the deliberate replication of the genetic makeup of another single individual (asexual reproduction). Human cloning, therefore, is the asexual production of a new human organism that is, at all stages of development, genetically virtually identical to a currently existing or previously existing human being.

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By / Apr 24

For the first time, scientists have cloned cells from two adults to create human embryos. This technical breakthrough follows similar research last year, which created cloned embryos from infant and fetal cells. Here is what every Christian should know about human cloning: 

What is cloning?

Cloning is a form of reproduction in which offspring result not from the chance union of egg and sperm (sexual reproduction) but from the deliberate replication of the genetic makeup of another single individual (asexual reproduction). Human cloning, therefore, is the asexual production of a new human organism that is, at all stages of development, genetically virtually identical to a currently existing or previously existing human being.

How does therapeutic cloning differ from reproductive cloning?

The use of the term 'therapeutic' and 'reproductive in reference to cloning is misleading. All cloning produces a human embryo and is therefore reproductive in nature. The more accurate phrasing is 'cloning-to-produce-children' and 'cloning-for-research' to make a distinction between cloning that results in the creation of an embryo for subsequent destruction and one that is created in order to continue the normal process of human development.

What is the process of human cloning?

Cloning is achieved by a technique referred to as somatic cell nuclear transfer (SCNT). The process involves introducing the nuclear material of a human somatic cell (donor) into an oocyte (egg cell) whose own nucleus has been removed or inactivated, and then stimulating this new entity to begin dividing and growing, yielding a cloned human embryo.

Does cloning produce an exact genetic replica of the donor?

No. All human cells, including eggs and sperm, contain small, energy-producing organelles called mitochondria. Mitochondria contain a small piece of DNA that specifies the genetic instructions for making several essential mitochondrial proteins. SCNT transfers the nucleus into the oocyte, which contains mitochondrial DNA of the egg donor. Just as in sexual reproduction, the embryo produced by cloning contains genetic material from two different individuals.

How do the harvested cells from a cloned embryo differ from those produced by sexual reproduction or in-vitro fertilization?

Due to missing, but crucial interactions between the sperm and egg, genetic reprogramming errors’ are inherent to cloning. This leads to random, widespread genetic ‘imprinting’ and epigenetic defects that are both known causes of cancer. In addition to the epigenetic defects, cells derived from cloning that are injected back into the donor are rejected because of epigenetic mis-expression, genetic differences due to mitochondrial DNA, and the incompatibility of cells too immature in development to interact with adult tissue environments. This is the major stumbling block for using material from cloned embryos for the treatment of diseases.

What are the ethical problems concerning human cloning?

The primary moral objection to cloning-for-research is the same as for all embryo-destructive research—it creates human life solely for the purpose of destroying it; using a human embryo merely as a means to an end (e.g., "spare parts").

The objection to cloning-to-produce children are similar in that it poses a threat to the life of the child, and potentially to the birth mother. Even if the process could be made safe, though, it has the potential to alter the "DNA ecosystem" in ways that are un-predictable and thus potentially injurious to human and non-human life. For these reasons, Christians should continue to oppose all forms of human cloning as unethical and unnecessary.

Isn’t concern about the moral status of the embryo based on religious premises? Why should someone who doesn’t agree with that position reject cloning?

While it is true that many people oppose the cloning of human embryos for religious and ethical reasons, the issue is not divided along the typical left/right political spectrum. Even pro-choice advocates and others who hold liberal and progressive political views find sufficient ethical concerns for opposing the procedure.

The progressive International Center for Technology Assessment, for example, highlights the concerns that cloning will lead to the exploitation of women:

In recent testimony, one researcher stated that stem cells might be able to provide up to 1.7 million therapies per year. This would require a minimum of 5-8 million human eggs per year — assuming a very optimistically high success rate of 1 stem cell culture out of 3-5 clonal embryos. Where will researchers get these millions of eggs? From women in this country or abroad, and it is highly likely that many of these women will have to become repeat donors. Egg donation can have significant health impacts on women. Of particular concern are (1) the super-ovulating drugs that women are given in order to provide the eggs for embryo cloning, (2) numerous hormone treatments given to ease egg extraction, and (3) the extraction process itself. Risks to women from egg donation include a potential link to ovarian cysts and cancers, severe pelvic pain, rupture of the ovaries, bleeding into the abdominal cavity, acute respiratory distress, pulmonary embolism, and possible negative effects on future fertility. Most women who are lured into this process are economically disenfranchised and perform this operation because they are in financial need and seek payment for their eggs.

Doesn't a ban on therapeutic cloning remove a promising venue for biomedical research?

Currently, the primary justification for therapeutic cloning is as a means of harvesting embryonic stem cells. Any therapies that would result from the technique would likely come from that use. Cloning, however, not only compounds the ethical concerns of embryonic stem cell (ESC) research but also adds a significant number of other moral problems. This Machiavellian approach would be difficult to justify even if ESC research were to lead to miraculous cures.

But ESC research has proven to be a failure. There are more than 70 conditions currently being treated with adult stem cells, and zero with embryonic stem cells. Despite the media hype of the early 2000s, embryonic stem cell research has proven to be useless at treating medical conditions. When tested on animals, embryonic stem cells turned into tumors. As biological engineer James Sherley once explained, “Figuring out how to use human embryonic stem cells directly by transplantation into patients is tantamount to solving the cancer problem.”

When time and money are limited it's both irrational and immoral to divert funding and attention from promising areas of research to ones that have absolutely no evidence of producing results.

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